KLK2 - kallikrein related peptidase 2 Gene

Also Known as hK2; hGK-1; KLK2A2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3817

About KLK2

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,873,439-50,880,567 (from NCBI)

This gene has 23 transcripts (splice variants), 144 orthologues, 12 paralogues and is associated with 48 phenotypes. Restricted expression toward prostate (RPKM 1047.4).

Summary

This gene encodes a member of the grandular Kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate Cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]

KLK2 Products (3)

mRNA Protein Name
NM_001002231.3 NP_001002231.1 kallikrein-2 isoform 2 preproprotein
NM_001256080.2 NP_001243009.1 kallikrein-2 isoform 3
NM_005551.5 NP_005542.1 kallikrein-2 isoform 1 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
9042371 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLK2 Protein Structure

Trypsin

Trypsin: Trypsin (25 - 253)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

kallikrein-2

  • glandular kallikrein 2

Recombinant KLK2 Proteins

Cat. No. Product Name Accession Purity
HY-P70317 Kallikrein-2 Protein, Human (HEK293, His) P20151-1 (P19-P261) ≥ 95%, as determined by reducing SDS-PAGE.

KLK2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82984 Kallikrein 2 Antibody (YA2729) WB, ICC/IF Human, Mouse, Rat
HY-P84164 Kallikrein 2 Antibody (YA3861) IHC-P, ICC/IF, FC, ELISA Human
HY-P84164A Kallikrein 2 Antibody (YA3861)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Prostate Disease

  • Prostatic Diseases

  • Prostate Diseases
Prostatic Hyperplasia, Benign

  • Benign Prostatic Hyperplasia

  • BPH

  • Prostatic Hyperplasia
Prostatic Hypertrophy

  • Benign Prostatic Hypertrophy

  • Prostatic Hyperplasia
Primary Cutaneous Amyloidosis

  • Plca

  • Primary Localized Cutaneous Amyloidosis

  • Familial Primary Localized Cutaneous Amyloidosis

  • Amyloidosis Ix

  • Lichen Amyloidosis Familial

  • Amyloidosis, Primary Cutaneous

  • Pca

  • Amyloidosis 9

  • Amyloidosis Familial Cutaneous Lichen

  • Fplca

  • Familial Lichen Amyloidosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07380 KLK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183667 JNJ-pan-AR Inhibitor / Unkown
HY-181970 XY25026 Inhibitor / Unkown
HY-181971 XY25028 Inhibitor / Unkown
HY-183287 Androgen receptor antagonist-14 Antagonist / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991015 Pasritamig Inhibitor 99.031% Unkown
HY-P990608 Alpitatug 99.13% Unkown

Orthologs Information

Species Symbol Source ID
Others KLK2 NCBI